Serum ratio of AST/ALT, the so-called “De Ritis ratio (DRR)”, has been reported to be a valuable marker in differentiating varying causes of liver disease [9,13,14], surrogating different kinds of malignancies [13,15,16,17,18,19,20,21], and provides valuable information on the risk assessment of patients with heart diseases [22,23,24], acute kidney injury [25,26,27], sepsis [28], and even patients with COVID-19 [29,30,31,32]. The gene discussed is GPT; the disease is liver disorder.