NSD1 and cancer: NSD1 is vital for normal growth and development, and any alteration in the expression of NSD1 can lead to a developmental defect such as SOTOS syndrome [2] and cancers, including neuroblastoma, glioblastoma [3], head and neck squamous cell carcinoma (HNSCC) [4], lung carcinoma [5], renal carcinoma [6], and hematological cancers such as acute myeloid leukemia (AML) (6).