Among the 40 cancer and non-cancer disorders studied, the median CA125 serum levels in individuals with pulmonary fibrosis and cirrhosis were 52.04 and 52.34 U/mL, respectively, with the mean value elevated to 165.32 U/mL in cirrhosis and 79.01 U/mL in pulmonary fibrosis. Here, MUC16 is linked to pulmonary fibrosis.