The APP protein is encoded by the APP gene (Figure 2), which has 17 transcripts (splice variants), 279 orthologues, 2 paralogues, and is associated with 9 phenotypes (ABeta amyloidosis Arctic type, ABeta amyloidosis Dutchr type, ABeta amyloidosis Iowa type, ABeta amyloidosis Italian type, ABetaA21G amyloidosis, ABetaL34V amyloidosis, ADs, cerebral amyloid angiopathy APP-related, and early-onset autosomal dominant AD). The gene discussed is APP; the disease is amyloidosis.