We did not find significant differences between cohorts in terms of age, gender, anthropomorphic parameters, the presentation of dyslipidemia, hypertension, coronary artery disease, smoking and HF phenotypes, nor in terms of systolic and diastolic blood pressure, LVEDV, LVESV, LVEF, eGFR, NT-proBNP levels, HOMA-IR scores, creatinine levels, lipid profiles and concomitant medications. The gene discussed is NPPB; the disease is Hypertension.