Considering all these anti-tumoral effects of anti-PCSK9 approaches and taking into account the existence of a wide variety of therapeutic strategies of PCSK9 blockade (monoclonal antibodies, small molecule and peptide inhibitors, antisense oligonucleotides, siRNA, etc.), the expectations are high in terms of seeing this multifaceted protein as a very valuable and attractive target for the future potential treatment of liver cancers. Here, PCSK9 is linked to liver cancer.