On the other hand, in another study using different HCC cell lines (HepG2 and LM3), PCSK9 expression was enhanced using acRoots (Actinidia chinensis Planch root extract), resulting in decreased LDLR expression, the inhibition of LDL uptake by LM3 cells, the decrease in the intracellular cholesterol levels and thus diminished proliferation. Here, PCSK9 is linked to hepatocellular carcinoma.