However, a massive decrease in the levels of LDLR and LRP1 was observed in the non-tumor tissues, suggesting that the increased SREBP2 expression triggers the increase and secretion of PCSK9, which in turn downregulates the lipoprotein receptors in the non-tumor tissue, hence resulting in paraneoplastic hyperlipoproteinemia [79]. Here, PCSK9 is linked to neoplasm.