The results show that the over-expression of C-MYC could inhibit NCOA4 expression, while C-MYC down-regulation could promote NCOA4 expression (Figure 1G), indicating that C-MYC might inhibit downstream NCOA4 expression through interfering with the stability of its mRNA and promoting its degradation in ovarian cancer cells. The gene discussed is MYC; the disease is ovarian cancer.