In contrast to many previous experiments, which do not consider all five (α, β, γ, δ, ε) representatives of AP-2 family at once (even our previous research focused on the two best-described ones), the present study examines the relevance of each AP-2 member to be selectively recognized; it then identifies the best AP-2 protein from the point-of-view of selective ligandability and provides related data about its mutations, genetic targets, transcriptional co-factors and correlated genes in a pan-cancer spectrum. This evidence concerns the gene TFAP2A and cancer.