In this study, three herbal drugs have been selected which are known for their application in herbal cancer therapy (apigenin, quercetin, and resveratrol), targeting the top three proteins which appear to be highly dominant based on our crosstalk analysis (Figure 6); we observe that the delta G values are very close to each other for apigenin and quercetin, which means a higher possibility to have a binding site for the three selected proteins GSK3B, HIF1A, and YWHAE. The gene discussed is HIF1A; the disease is cancer.