Upregulation of MEG3 [32], TRIM4 [33], and TCEAL5 [34] were reported in different models of Huntington’s disease with an intracellular aggregation of mutant HTT, suggesting a link between PSEN1 ΔE9 and mutant HTT-induced transcriptomic changes. The gene discussed is PSEN1; the disease is juvenile Huntington disease.