Consequently, we retrieved the survival analysis data of these 16 genes in GEPIA2, and the elevated expression level of 8 genes led to a better prognosis for colorectal cancer patients: ACADM, ACADS, GPX4, GSR, HADH, HMGCL, HMGCS1 and IDH1 (p < 0.05) (Figure 1D). The gene discussed is HMGCS1; the disease is colorectal cancer.