Therefore, we used the correlation of the expression level of genes with the prognosis of colorectal cancer patients as an evaluation index, and finally identified eight critical enzymes of amino acid metabolism in colon TAMs, namely, ACADM, ACADS, GPX4, GSR, HADH, HMGCL, HMGCS1 and IDH1. Here, HMGCS1 is linked to colorectal cancer.