A hyperkeratosis disorder, epidermolytic ichthyosis, a rare genodermatosis caused by mutations in keratins 1 or 10, has a profile of keratin dysregulation that may be counter-regulated by cannabinoids, as recently shown in an image correlation describing that ACEA upregulates the expression of keratin 10 in human epidermis and decreases the expression of keratin 1 in human skin organ culture [383]. Here, KRT1 is linked to epidermolytic ichthyosis.