In a recent report, CB2 receptor expression was observed to be increased in dermatomyositis in certain cell types found in the skin, such as dendritic cells, B-cells, T-cells and macrophages, which produce IL-31, IL-4, interferon (IFN)-γ and IFN-β, compared to healthy skin [8]. This evidence concerns the gene IFNB1 and dermatomyositis.