The focus here was on the distribution of cannabinoid receptors in the individual components of the skin, with strong CB1 immunoreactivity observed in the keratinocytes of the suprabasal spinous layers of the epidermis and strong CB2 immunoreactivity in the basal, suprabasal and granular layers of the epidermis in dogs with atopic dermatitis. Here, CNR1 is linked to atopic eczema.