However, Jarocka-Karpowicz et al. [7] showed that CBD increased AEA levels, upregulated CB1 receptors in UV-irradiated keratinocytes from healthy and psoriasis patients, increased CB2 receptors in keratinocytes from healthy and psoriasis patients and decreased CB2 expression in UV-irradiated keratinocytes from psoriasis patients. The gene discussed is CNR2; the disease is psoriasis.