TAMs regulate tumor growth, angiogenesis, metastasis, and drug resistance by producing cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6 and IL-1β, and chemokines such as CXC chemokine ligand 1 (CXCL1) and CXCL2 [7]. Here, CXCL1 is linked to neoplasm.