When both CFTR alleles are mutated, and the global CFTR activity is impaired by more than 70% (and often more than 95%), (see the CFTR2 database at https://cftr2.org, accessed on 3 November 2022), patients are affected by cystic fibrosis (CF), CF is multiorgan disease, mainly characterized by the high viscosity of secreted fluids, causing plugs and obstructions, and an excessive host inflammatory response [21]. Here, CFTR is linked to cystic fibrosis.