MYC and liver cancer: Two of these (“Mitochondrial structure/function” and “Ribosome biogenesis/translation”) were previously shown to contain numerous gene sets that were downregulated in murine hepatocytes bearing individual or combinatorial knockouts of Myc, Chrebp, and Mlx KO and upregulated in Myc-driven liver cancers [3,8,11] (Figure 5D, Figures S3 and S4).