MLXIPL and male infertility: Finally, global Mlx KO, which functionally inactivates both ChREBP and MondoA, does not affect normal embryonic development but does cause male infertility and apoptosis of germ cells, whereas Mlx KO in the liver inhibits long-term hepatocyte regeneration and proliferation of hepatoblastomas even more than Chrebp KO, although it is permissive for the development of benign hepatic adenomas [1,2,3].