Further supporting a tumor-suppressor-like role for Mlx are its partial silencing in immortalized Myc−/− rat fibroblasts, its direct correlation with Myc levels in some cancers (Figure 4J,K) [10,15], and its regulation of genes involved p53- and Rb-mediated growth suppression and G2/M blockage (Figure S20). This evidence concerns the gene RB1 and neoplasm.