When we examined the top 20 significantly upregulated biological process in COL1-PC3 and COL1-PC3SFRP2, we found that SFRP2 overexpression causes a significant upregulation of genes that are associated with “Cell morphogenesis involved in differentiation”, indicating a possible EMT required for cancer metastasis, as well as with “Biological Adhesion” and “Cell Adhesion”, which may be required for osteotropic relocation of metastatic prostate cancer cells. This evidence concerns the gene SFRP2 and cancer.