SFRP2 and Familial prostate cancer: When we examined the top 20 significantly upregulated biological process in COL1-PC3 and COL1-PC3SFRP2, we found that SFRP2 overexpression causes a significant upregulation of genes that are associated with “Cell morphogenesis involved in differentiation”, indicating a possible EMT required for cancer metastasis, as well as with “Biological Adhesion” and “Cell Adhesion”, which may be required for osteotropic relocation of metastatic prostate cancer cells.