SHBG and acne: Similarly, Walton et al. conducted a study of 36 women (aged 14–34) and found a significant correlation between the number of acne lesions and some of the five androgenic hormone determinants such as free testosterone, androstendione, the sex hormone binding globulin (SHBG), dehydroepiandrostenedione sulfate (DHEAS), and dihydrotestosterone (DHT).