In addition, there is increased androgen secretion during ACTH-dependent Cushing’s syndrome compared to the case of adrenal adenoma, which is probably related to the simultaneous stimulation by ACTH of the adrenal cortex cells responsible for adrenal steroidogenesis and excessive secretion of DHEA and testosterone [53,54]. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.