CD274 and neoplasm: A Wilcoxon rank-sum test was performed to compare a series of immune checkpoint expression level in the high-risk and low-risk groups, which indicated that there was significant difference in PDCD1, CD274, CTLA4, CD86, PDCD1LG2, LAG3, HAVCR2, and CXCL9 (p < 0.05), Figure 6G. Sequentially, the correlation of cytolytic activity (CYT, which represents tumor-infiltrating T lymphocyte activity and is related to prognosis) score and risk score was investigated, and the results showed that risk scores had a significantly negative link with CYT score (r = −0.31, p < 0.001, Figure 9A).