In our study, STS patients in the high-risk group indicated increased type 2 helper cell, but the majority of cases showed decreased cell types such as activated B cells, natural killer (NK) cells, CD4/8+ T cells, Th1/2 cells, eosinophil, dendritic cells, monocytes, neutrophils, and macrophages. The gene discussed is CD4; the disease is telomere syndrome.