High levels of plasmacytoma variant translocation 1 (PVT1) in serum-derived sEVs from patients with distant CRC metastases, as well as treatment of CRC cells with sEVs expressing PVT1, increased intracellular expression of EGFR and VEGFA and promoted EMT [52]. The gene discussed is EGFR; the disease is colorectal carcinoma.