To investigate the mechanism by which hepatocytes affect the development of liver metastasis in colorectal carcinoma, Xu et al. found that sEVs from hepatocytes inhibited Src expression and EGFR activation in CRC cells via miR-203a-3p and promoted E-cadherin re-expression, thereby inducing EMT. The gene discussed is EGFR; the disease is colorectal carcinoma.