SEVs derived from CRC cells overexpressing cationic amino acid transporter 1 (CAT1) significantly enhanced the growth of vascular endothelial cells and tubular formation, promoted angiogenesis, and accelerated CRC metastasis by regulating cGMP metabolism and up-regulating arginine transport and downstream nitric oxide metabolism [36]. This evidence concerns the gene SLC7A1 and colorectal carcinoma.