sEVs with downregulated ANGPTL1 decreased matrix metallopeptidase 9 (MMP9) levels in Kupffer cells (KCs) by inhibiting the JAK2-STAT3 signaling pathway, preventing hepatic vascular leakage and ultimately inhibiting the development of liver metastasis in CRC [75]. The gene discussed is ANGPTL1; the disease is colorectal carcinoma.