MALAT1 and colorectal carcinoma: Exposure to sEVs from highly metastatic CRC cells was shown to increase the invasive and metastatic capacity of primary CRC cells, and both in vivo and in vitro experiments have demonstrated that sEVs derived from highly metastatic CRC cells mediated hypo-metastasis through metastases-associated lung adenocarcinoma transcript 1 (MALAT1).