CRC cell-derived miR-146a-5p and miR-155-5p can be taken up by cancer-associated fibroblasts (CAFs) via sEVs and act through the JAK2-STAT3/NF-KB signaling pathway to suppress suppressor of cytokine signaling 1 (SOCS1) and zinc finger and BTB domain-containing 2 protein (ZBTB2). Here, STAT3 is linked to colorectal carcinoma.