Zeng et al. found that CRC cell-derived sEVs carrying miR-25-3p targeted Krüppel-like factor 2 (KLF2) and Krüppel-like factor 4 (KLF4) to regulate the expression of VEGFR2, ZO-1, occludin, and claudin-5 in endothelial cells, thereby promoting vascular permeability and angiogenesis. Here, KLF2 is linked to colorectal carcinoma.