It was shown that CRC cells release integrin beta-like 1 (ITGBL1)-rich sEVs into the circulation by stimulating tumor necrosis factor (TNF) alpha-induced protein 3 (TNFAIP3)-mediated nuclear factor kappa-B (NF-κB) signaling pathway activation in distant fibroblasts. The gene discussed is TNF; the disease is colorectal carcinoma.