RASA1 and colorectal carcinoma: In addition, researchers found that sEVs secreted by EMT-CRC cells further disrupted endothelial cell junctions by transferring miR-27b-3p into vascular endothelial cells and attenuating vascular endothelial cadherin (VE-Cad) and p120-catenin (p120) expression in a post-transcriptional manner.