Studies with IFNγ stimulation of a melanoma cell line in a time courses experiment from 3 h to 72 h [33] showed a progressive increase in significantly regulated mRNA and miRNA; miRNAs only become connected to biological functions at very late time points (48 h and 72 h), indicating that they are activated by downstream regulators from the activated JAK/STAT signaling cascade. The gene discussed is IFNG; the disease is melanoma.