SUN1 and Emery-Dreifuss muscular dystrophy: Whilst our searches found no mutations in the genes encoding integral LINC complex proteins SUN1/SUN2 were found to directly cause human disease, the presence of SUN1/SUN2 variants alongside other Emery-Dreifuss muscular dystrophy EDMD-related genes, including LMNA, cause a more severe EDMD phenotype [75].The synergistic effects of LMNA and DES (encoding desmin) or EMD mutations have also been found to alter EDMD disease severity [76,77,78].