One of the widest ranging examples among these is the p.Arg644Cys variant which has been linked to EDMD, LGMD, L-CMD, atrioventricular block (AVB), DCM, arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction, insulin resistance, FPLD, and CMT [30,38,39,40,41,42,43]. This evidence concerns the gene INS and familial dilated cardiomyopathy.