Mutations in LMNA, EMD, SYNE1/SYNE2 and TMEM43 for example, cause EDMD [21,22,23,24,25], while mutations in LMNA affecting the ubiquitously expressed lamin A/C protein lead to more than 15 distinct tissue-specific diseases (Figure 1) [26]. The gene discussed is SYNE2; the disease is Emery-Dreifuss muscular dystrophy.