Another study reports that in breast cancer cells, expression of the miR-106b-93-25 cluster results in NEDD4L down regulation and subsequent stabilization of Notch1, a direct target of NEDD4L ubiquitination [189]; Notch1 is generally overexpressed in GBM and is linked to lower overall survival [190]. This evidence concerns the gene NEDD4L and glioblastoma.