The UPS acts as a major regulator of induction of apoptosis in cancers including GBM through both degradative and non-degradative ubiquitination of apoptosis related proteins, such as the anti-apoptotic Bcl-2 and the pro-apoptotic Bcl-2-interacting protein 1 (BNIP1) [53]. Here, BCL2 is linked to glioblastoma.