NFE2L2 and age-related macular degeneration: As said before, DMF reacts with Keap1 protein leading to Nrf2 activation; we thus examined the link between Keap1 and AMD by consulting the gene–disease DisGeNet database, followed by investigation of Keap1’s multiple physical associations through protein–protein interaction (PPI) analyses (Figure 2); this search revealed that DMF may exert other additional beneficial biological effects on RPE cells than the ones already mentioned.