A metabolic crisis in pancreatic carcinoma cells was described after DMF treatment through the down-regulation of methylenetetrahydrofolate dehydrogenase (MTHFD1) and methylenetetrahydrofolate dehydrogenase (NADP+ Dependent) 1 Like (MTHFD1L), two enzymes implicated in folate metabolism [26]. The gene discussed is MTHFD1; the disease is exocrine pancreatic carcinoma.