STAT4 and Aortic dissection: It was revealed that 5’-tiRNA-Cys-GCA was decreased in human and mouse aortic dissection models, and 5’-tiRNA-Cys-GCA overexpression inhibited the proliferation and migration of vascular smooth muscle cells through STAT4, upregulated contractile markers, reduced the incidence of angiotensin II and β-aminopropionitrile-induced aortic dissection (AD) in mice and prevented its deterioration [76].