It has been shown that the transduction of FOXP3 and transgenic TCR coding sequences into miPSCs, and then the differentiation of these cells, led to the generation of functional Tregs secreting regulatory molecules, such as IL-10 and TGF-β, and enabled the control of autoimmunity in an arthritic mouse model [59,60]. This evidence concerns the gene IL10 and Autoimmunity.