In predicting the outcomes of normal or tumor tissues, the predictability of the RND/RAC/CDC42 subfamily genes such as RND3 (AUC = 0.968), RHOD (AUC = 0.936), RND2 (AUC = 0.869), RND1 (AUC = 0.840), RHOF (AUC = 0.837), RAC1 (AUC = 0.877), RAC3 (AUC = 0.869), RHOJ (AUC = 0.989) showed a high accuracy, while the RHO subfamily genes such as RHOA (AUC = 0.652), RHOB (AUC = 0.640), RHOC (AUC = 0.666) showed a lower accuracy (Figure 2) (Table S2). Here, RAC3 is linked to neoplasm.