CHST3 and Ehlers-Danlos syndrome: Herein, we demonstrated that hEDS and HSD dermal fibroblasts not only share a widespread ECM disarray and a myofibroblast-like phenotype, a combination that is not encountered in other EDS forms and HCTDs in which, however, a disorganization of several ECM structural components might be present [21], but also show a common dysregulated transcriptional signature compared to control fibroblasts.