Dysregulated transcription and chromatin reorganisation by mutant lamins is associated with a large number of laminopathies such as progeria, cardiomyopathy and muscular dystrophies; also, changes in lamin expression are associated with many cancers [84,85,86], and therefore it is plausible that vimentin-induced changes in lamin expression could suppress genes associated with cell–cell junctions. Here, VIM is linked to progeroid syndrome.