The authors developed liposomes encapsulating both a complex of doxorubicin with 1-bromomethyl-o-carborane (DOX-CB), which should translocate into the nucleus thanks to the DOX nuclear tropism, and the CD47 gene-targeted CRISPR-Cas9 gene knock-out plasmid (pDNA) that, by directly knocking out the CD47 gene, promotes the macrophage-mediated phagocytosis of cancer cells. The gene discussed is CD47; the disease is cancer.