Expression changes in TLR1, TLR2, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, and TLR10 have been often reported in obesity, metabolic syndrome, inflammation and insulin resistance, T2D, and related complications such as cardiovascular disease, diabetic nephropathy, and atherosclerosis [23,24,25,26,27,28,29,30,31,32,33,34]. This evidence concerns the gene TLR9 and type 2 diabetes mellitus.