Regarding expression of TLRs, their downstream signaling mediators and IRFs, adipose expression of TLR2 (p = 0.018), TLR3 (p = 0.010), TLR8 (p = 0.048), IRAK1 (p = 0.047), and IRF5 (p = 0.016) was significantly higher in participants with obesity compared to NW participants. The gene discussed is TLR8; the disease is obesity due to melanocortin 4 receptor deficiency.