In conclusion, our data show that the AT SRA1 expression correlates with TLRs-3,4,7,9, MyD88, NF-κB, and IRF5 expression in individuals with T2D and with TLR2, IRAK1, and IRF3 expression in individuals with obesity. This evidence concerns the gene IRF5 and obesity due to melanocortin 4 receptor deficiency.