Expression changes in TLR1, TLR2, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, and TLR10 have been often reported in obesity, metabolic syndrome, inflammation and insulin resistance, T2D, and related complications such as cardiovascular disease, diabetic nephropathy, and atherosclerosis [23,24,25,26,27,28,29,30,31,32,33,34]. The gene discussed is TLR2; the disease is type 2 diabetes mellitus.