Expression changes in TLR1, TLR2, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, and TLR10 have been often reported in obesity, metabolic syndrome, inflammation and insulin resistance, T2D, and related complications such as cardiovascular disease, diabetic nephropathy, and atherosclerosis [23,24,25,26,27,28,29,30,31,32,33,34]. Here, TLR4 is linked to type 2 diabetes mellitus.