In addition, we explored the proteins expressed by REEP6, LARP4B, CWC27, GOLGA2, ATP6AP1 and ERO1B in glioma patients through the HPA database, and REEP6, LARP4B, GOLGA2 and ATP6AP1 showed higher staining intensity in glioma than in normal brain tissue (Supplementary Figure S2A–F). The gene discussed is REEP6; the disease is central nervous system cancer.