MGMT and neoplasm: Moreover, the ROC curve of SC2I and other clinical characteristics revealed that its predictive performance (AUC = 0.959) was better than other classical indicators, including tumor subtype (AUC = 0.778), WHO grade (AUC = 0.906), IDH mutation status (AUC = 0.132), MGMT promoter status (AUC = 0.321) and age (AUC = 0.809) (Figure 4E).