SCAND1 and neoplasm: Furthermore, SCAND1 and MZF1 expression was negatively correlated with TGFBR1, TGFBR2, and TGFBR3 gene expression (Figure 4E), suggesting that SCAND1-MZF1 could reduce TGFβ receptors to narrow down TGFβ signals emanating from the microenvironment to tumor cells.