In a published report on endometrial carcinoma [25], Chang et al. found that the circulating CD4+ T-cells expressed significantly higher CCR7+ CD45RO- (a marker for Naïve CD4+ T-cells) and CCR7+ CD45RO+ (a marker for CM CD4+ T-cells), but lower CCR7-CD45RO+ (a marker for EMRA CD4+ T-cells) than the infiltrating CD4+ T-cells; while the circulating CD8+ T-cells expressed higher CCR7+ (markers of the progenitor cells in CD8+ T-cells) than the infiltrating CD8+ T-cells. The gene discussed is CD8A; the disease is endometrial carcinoma.