Despite NASH-associated ACOX2 and BAAT down-regulation, alteration in the proportion of C27-BA intermediates in serum was not found (Figure 8C), and the ratio of conjugated versus non-conjugated BAs was not decreased but, on the contrary, was increased in NASH patients (Figure 8D–F). The gene discussed is BAAT; the disease is metabolic dysfunction-associated steatohepatitis.