CD30, or TNFRSF8, is a member of the TNF receptor superfamily and is expressed by small subsets of normal B and T cells, as well as in several malignancies including HL, ALCL, ATLL, and PTCL [82,83,84]. This evidence concerns the gene TNFRSF8 and mature T-cell and NK-cell non-Hodgkin lymphoma.