IL18R1 and inborn error of immunity: GSEA identified immune response (red dots) and cell–cell interaction (green dots)-associated biological processes enriched by genes deregulated in ΔmenRNA cells (Inset): primary immunodeficiency, cytokine-cytokine receptor interaction, JAK-STAT-signaling [18], hedgehog signaling [19,20], focal adhesion, GAP junction, extracellular matrix receptor interaction, regulation of actin cytoskeleton.