These tRNA-like transcripts appear to be prototypes of a class of ncRNAs distinct from other small transcripts (miRNAs, siRNAs) by biosynthetic pathway (enzymatic excision from lncRNAs) and intracellular kinetics, suggesting a novel link for the apparent relevance of the NEAT1-MALAT1 cluster in cardiovascular and neoplastic diseases. This evidence concerns the gene MALAT1 and neoplasm.