circRNA_002581 knockdown significantly attenuated lipid droplet accumulation, decreased alanine aminotransferase (ALT) levels, aspartate aminotransferase (AST), pro-inflammatory cytokines, apoptosis, and hydrogen peroxide, and raised the level of ATP in both mouse and cellular models of NASH (Figure 3) [179]. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.