The activation of the AKT/PI3K/mTOR pathway in tumor cells has been found to increase VEGF secretion and plays an essential role in angiogenesis regulation by modulating endothelial cell migration, the formation of structurally abnormal blood vessels, as well as the expression of nitric oxide and angiopoietins in normal tissues and in cancers [29]. The gene discussed is AKT1; the disease is neoplasm.