In conclusion, LED with a wavelength of 590 nm alleviated angiogenesis through inhibiting HMEC-1 migration, tube formation, as well as the synthesis and secretion of VEGF through the AKT/PI3K/mTOR pathway and might suppress melanogenesis via decreasing the release of SCF, which could be a novel therapeutic modality for melasma. This evidence concerns the gene VEGFA and freckles.