Our recent study in diabetic nephropathy showed that hidrosmin actions are mediated by the concerted inhibition of NF-κB and Signal Transducer and Activator of Transcription 3 (STAT3) in renal cells [30], which is in line with the normalization of renal NF-κB activity reported for diosmin in diabetic rats [57]. Here, NFKB1 is linked to diabetic kidney disease.