However, to the best of our knowledge, this study combining two complementary experimental models is the first to demonstrate the positive impact of hidrosmin on vascular function in aorta and mesenteric arteries of db/db mice and atherosclerotic plaques of diabetic ApoE KO mice, which are corroborated in vitro in endothelial cells and hyperglycemia-exposed VSMC. This evidence concerns the gene APOE and Hyperglycemia.