Additionally, the protein expressions of laminin, fibronectin, and collagen I, three indicators of ECM, displayed an identical pattern of MMPs among the groups, implying that inappropriate accumulation of ECM in kidney parenchyma of CKD could be a very common abnormal issue that compressed the space of renal tubules, i.e., the sparrow’s nest is occupied by a pigeon (referring to Figure 6). This evidence concerns the gene FN1 and chronic kidney disease.