However, after inhibiting the expression of Nrf2 in rats and HK2 cells, the antioxidant, anti-apoptosis and anti-ferroptosis abilities of dioscin were dramatically attenuated, indicating that the protective effect of dioscin on cisplatin-induced AKI is closely related to the up-regulation of Nrf2/HO-1 signaling. Here, NFE2L2 is linked to acute kidney injury.