Altogether, this is in line with the results from our correlation analyses that showed negative associations with markers of hyperglycemia (i.e., mean and AUC values for glucose), hyperinsulinemia (i.e., fasting insulin, HOMA-IR), and dyslipidemia (i.e., CRI-I, LDL-C, TC), and positive correlations with variables related to healthy insulin sensitivity (i.e., WBISI) and lipid profile (i.e., HDL-C) (Figure 1A,B). The gene discussed is INS; the disease is hyperinsulinism.