TF and obesity due to melanocortin 4 receptor deficiency: This pathological condition has not been described to date in obesity, but it has been extensively investigated in Alzheimer’s disease, where increased content of labile iron and copper has been associated with profound impairments in the proteins that regulate their trafficking, including decreased ability of ferritin to retain iron, disturbed transferrin-mediated transport, and ceruloplasmin fragmentation [25].