Importantly, the fact that other mouse models of DS, such as the Ts1Cje mouse model, do not contain Sod1 in the trisomic segment, but have increased OS in different brain regions, suggests that other triplicated genes, including Dscr1 or Dyrk1A, could also be implicated in the enhanced OS found in DS [89]. Here, DYRK1A is linked to Dravet syndrome.