Both O2•− and H2O2 are increased in vascular cells in experimental models of hypertension including SHR/SHRSP rats, DOCA rats, angiotensin II-induced mice, and transgenic mice overexpressing smooth muscle cell-specific NOX1 [266,267,268,269,270,271,272,273,274,275]. The gene discussed is NOX1; the disease is hypertensive disorder.