Scavenging of mitochondrial isolevuglandins formed by peroxidation of arachidonic acid with Mito2HOBA and targeting cyclophilin D, a component of mitochondrial permeability transition pore, with its specific inhibitor sanglifehrin A reduce vascular mitochondrial ROS, improve vascular function, and attenuate hypertension in Ang II-infused mice [362,419]. The gene discussed is AGT; the disease is Hypertension.