This is in contrast to prior reports demonstrating a compensatory increase in the NRF-2 associated genes Nqo1, Gclc and Hmox1, as well as other reports demonstrating an increase in non-Se containing AOE in lung or liver after dietary Se deficiency as well as genetic or pharmacologic Txnrd inhibition [35,40,41,42,53,54,70,71,72,73,74] There are several possible explanations why the neonatal SeD lung did not elicit a similar response despite decreased Txnrd activity. This evidence concerns the gene HMOX1 and spondyloepiphyseal dysplasia.