Interestingly, although pharmacological inhibition of FSP1 (by iFSP1), as in the case of GPX4 inhibition (by RSL3), did not induce cell death, a combination of iFSP1 and RSL3 compromised the survival of the CRC cells, with approximately 50% cell death after 24 h of treatment (Supplementary Figure S1). This evidence concerns the gene GPX4 and colorectal carcinoma.