Among these, SFN alleviated UC by regulating gut microbiota composition, increasing the content of volatile fatty acids and the expression of tight function proteins, and reducing pro-inflammatory cytokines, ISO attenuated DSS-induced colitis through the activation of nuclear transcription factor kappa B and the inhibition of the mitogen-activated protein kinase pathway and the caffeic acid phenethyl ester derivative-activated Nrf2/HO-1 pathway to alleviate DSS-induced colitis against oxidative stress. This evidence concerns the gene HMOX1 and colitis.