Recently, a new study confirmed that knockdown of the lncRNA KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) downregulated PDCD4 by targeting miR-181a-5p and inhibited myocardial inflammation and apoptosis in DCM [66]. This evidence concerns the gene KCNQ1OT1 and familial dilated cardiomyopathy.