Significantly elevated mRNA and protein levels of LSD1/KDM1A, along with up-regulated transcript levels of KDM2A, KDM3A, KDM4A, KDM5A, and KDM5B subtypes, were determined in the aorta of ApoE-/- mice with established atherosclerosis, an experimental set-up that recapitulated to some extent important pathophysiological characteristics of human atherosclerotic disease [19]. Here, APOE is linked to atherosclerosis.