The antioxidant effects of the ACE2/ Ang-(1-7)/MasR pathway in the brain were confirmed by a study in which the ACE2 agonist xanthenone reduced oxidative damage and increased glutathione level (the main non-enzymatic antioxidant) in rat model of cerebral ischemia/reperfusion injury [56]. The gene discussed is ACE2; the disease is Cerebral ischemia.